Thursday, June 30, 2022

Scientists engineer synthetic DNA to study 'architect' genes

Researchers have created artificial Hox genes -- which plan and direct where cells go to develop tissues or organs -- using new synthetic DNA technology and genomic engineering in stem cells. Their findings confirm how clusters of Hox genes help cells to learn and remember where they are in the body.

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Dissolving implantable device relieves pain without drugs

Researchers have developed a small, soft, flexible implant that relieves pain on demand and without the use of drugs. The first-of-its-kind device could provide a much-needed alternative to opioids and other highly addictive medications. It works by softly wrapping around nerves to deliver precise, targeted cooling, which numbs nerves and blocks pain signals to the brain. After the device is no longer needed, it naturally absorbs into the body -- bypassing the need for surgical extraction.

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Sleep triggered by stress can help mice cope with later anxiety

Stress boosts a kind of sleep in mice that subsequently relieves anxiety, according to new research that also pinpoints the mechanism responsible.

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Cosmological thinking meets neuroscience in new theory about brain connections

A collaboration between a former cosmologist and a computational neuroscientist generates a new way to identify essential connections between brain cells.

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Optical fiber imaging method advances studies of Alzheimer's disease

An optical fiber as thin as a strand of hair holds promise for use in minimally invasive deep-tissue studies of patients' brains that show the effects Alzheimer's disease and other brain disorders. The challenge is efficiently increasing image resolution at the subcellular level, because loss of information is inevitable from light scrambling.

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Breaking AIs to make them better

Current AIs are very accurate but inflexible at image recognition. Exactly why this is remains a mystery. Researchers have developed a method called 'Raw Zero-Shot' to assess how neural networks handle elements unknown to them. The results have the potential to help researchers identify the common features that make neural networks 'non-robust,' and develop methods to make AIs more reliable.

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A closer look into the emergence of antibiotic resistance in bioaerosols and its monitoring

While there are many studies that discuss antibiotic resistance genes (ARG) in soil and water environments, there is currently very little research that focuses on ARG in aerial environments. In a recent review, researchers have analyzed current research trends regarding ARG in bioaerosols, including their sources, methods of detection, and implications for the future.

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How bacteria adhere to cells: Basis for the development of a new class of antibiotics

Researchers have unraveled how bacteria adhere to host cells and thus taken the first step towards developing a new class of antibiotics.

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Wednesday, June 29, 2022

Only 1 in 5 people in the U.S. has optimal heart health

Researchers found the U.S. population is well below optimal levels of cardiovascular health after applying the Life's Essential 8™ cardiovascular health scoring, the American Heart Association's updated metrics to measure heart and brain health. Life's Essential 8™ scoring was calculated using data from more than 23,400 adults and children from national health surveys from 2013-2018. Results show 80% of people in the U.S. have below-optimal cardiovascular health, and scores differed significantly according to age, gender, race/ethnicity, family income and depression status.

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Sleep added to cardiovascular health checklist

American Heart Association's checklist to measure cardiovascular health is updated, now called Life's Essential 8™, adding healthy sleep as essential for optimal cardiovascular health. Other health and lifestyle factors in the checklist, which were part of the previous, 7-item scoring tool, are nicotine exposure, physical activity, diet, weight, blood glucose, cholesterol and blood pressure. The new sleep metric suggests 7-9 hours of sleep daily for optimal cardiovascular health for adults, and more for children depending on age.

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Mantle cell lymphoma treatment varies according to setting

There is considerable variation in the management of mantle cell lymphoma across different clinical settings, and some strategies do not always conform with what might be expected, according to a recent analysis.

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Chemical risk assessment not up to par, researchers say

The current system of chemical risk assessment is inadequate and underestimates levels of flame retardants and other pollutants needed to cause harmful health effects, according to a recent analysis.

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Chemical risk assessment not up to par, researchers say

The current system of chemical risk assessment is inadequate and underestimates levels of flame retardants and other pollutants needed to cause harmful health effects, according to a recent analysis.

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Tuesday, June 28, 2022

Electrospinning promises major improvements in wearable technology

Researchers examine some of thelatest advances in wearable electronic devices and systems being developed using electrospinning -- the fabrication of nanofibers with tunable properties from a polymer base -- and showcase the many advantages electrospun materials have over conventional bulk materials. Their high surface-to-volume ratio endows them with enhanced porosity and breathability, which is important for long-term wearability, and with the appropriate blend of polymers, they can achieve superior biocompatibility.

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Seat assignments drive friendships among elementary school children

Most teachers focus on academic considerations when assigning seats. A new study is the first to show that these classroom seat assignments also have important implications for children's friendships and the enormous influence that teachers wield over the interpersonal lives of children. Friendships reflect classroom seat assignments. Students sitting next to or nearby one another were more likely to be friends with one another than students seated elsewhere in the classroom. Moreover, longitudinal analyses showed that classroom seating proximity was associated with the formation of new friendships. After seat assignments changed, students were more likely to become friends with newly near-seated classmates than with those who remained or became seated farther away.

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How did vertebrates first evolve jaws?

Scientists reveal clues about the evolutionary origin of jaws by studying the embryonic development of zebrafish -- an approach known as 'evo-devo.' Using imaging and cell tracing techniques in zebrafish, researchers who conducted the study conclusively showed that the pseudobranch originates from the same mandibular arch that gives rise to the jaw.

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Microfluidic-based soft robotic prosthetics promise relief for diabetic amputees

Scientists reveal their development of a new type of prosthetic using microfluidics-enabled soft robotics that promises to greatly reduce skin ulcerations and pain in patients who have had an amputation between the ankle and knee. They started with a recent device that uses pneumatic actuators and miniaturized the actuators by designing a microfluidic chip with 10 integrated pneumatic valves to control each actuator. The control box is small and light enough to be worn as part of the prosthesis.

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Defining plasma dose for potential future cancer treatments

Researchers may have found a new approach to treat cancer by using a plasma treatment to induce apoptosis, without any obvious side effect to normal cells. A plasma-activated medium (PAM) can be treated as a drug, with a dose-effect relationship.

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Monday, June 27, 2022

Heat waves could lead to avian population decline

Researchers examined how heat impacts the behavior and physiology of Zebra finches. They discovered that heat altered the activity of hundreds of genes in the testis, but fewer in the brain, suggesting that the brain may be less responsive to extreme temperatures. The study also provided some hopeful insights for birds and their ability to handle the threat of climate change.

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Heat waves could lead to avian population decline

Researchers examined how heat impacts the behavior and physiology of Zebra finches. They discovered that heat altered the activity of hundreds of genes in the testis, but fewer in the brain, suggesting that the brain may be less responsive to extreme temperatures. The study also provided some hopeful insights for birds and their ability to handle the threat of climate change.

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Biodiversity risks to persist well beyond future global temperature peak

Even if global temperatures begin to decline after peaking this century because of climate change, the risks to biodiversity could persist for decades after.

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Supernumerary virtual robotic arms can feel like part of our body

Researchers have developed a virtual robotic limb system which can be operated by users' feet in a virtual environment as extra, or supernumerary, limbs. After training, users reported feeling like the virtual robotic arms had become part of their own body. This study focused on the perceptual changes of the participants, understanding of which can contribute to designing real physical robotic supernumerary limb systems that people can use naturally and freely just like our own bodies.

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The effect of breast cancer screening is declining

A new research result questions whether the benefits of breast cancer screenings has gradually declined to a degree that it is too small in relation to the costs in the form of overdiagnosis and overtreatment.

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Thin-film photovoltaic technology combines efficiency and versatility

Stacking solar cells increases their efficiency. Researchers have now produced perovskite/CIS tandem solar cells with an efficiency of nearly 25 percent -- the highest value achieved thus far with this technology. Moreover, this combination of materials is light and versatile, making it possible to envision the use of these tandem solar cells in vehicles, portable equipment, and devices that can be folded or rolled up.

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Ancient microbes may help us find extraterrestrial life forms

Using light-capturing proteins in living microbes, scientists helped reconstruct what life was like for some of Earth's earliest organisms. These efforts could help us one day recognize signs of life on other planets.

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Novel, sensitive, and robust single-cell RNA sequencing technique outperforms competition

Single-cell RNA sequencing (scRNA-seq) is one of the most important methods to study biological function in cells, but it is limited by potential inaccuracies in the data it generates. Now, a research team has developed a new method called terminator-assisted solid-phase complementary DNA amplification and sequencing (TAS-Seq), which overcomes these limitations and provides higher-precision data than existing scRNA-seq platforms.

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Supernumerary virtual robotic arms can feel like part of our body

Researchers have developed a virtual robotic limb system which can be operated by users' feet in a virtual environment as extra, or supernumerary, limbs. After training, users reported feeling like the virtual robotic arms had become part of their own body. This study focused on the perceptual changes of the participants, understanding of which can contribute to designing real physical robotic supernumerary limb systems that people can use naturally and freely just like our own bodies.

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Sunday, June 26, 2022

Built infrastructure, hunting and climate change linked to huge migratory bird declines

New research shows how migratory birds are declining globally because of the way that humans have modified the landscape in recent decades. A total of 103 species of migrating birds were studied, including rapidly declining species like the turtle dove and the common cuckoo, using large-scale datasets. Advances in satellite imagery allowed the team to map threats across Europe, Africa and Western Asia.

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Friday, June 24, 2022

'Brain bleeds' in babies first year can lead to long-term sight problems, study finds

Severe 'brain bleeds' experienced by some babies in the first year following their birth can lead to long-term sight problems, researchers have found as part of a ten-year follow-up study.

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Light traveling in a distorting medium can appear undistorted

Researchers have made a new discovery on how light behaves in complex media, media that tends to distort light significantly. They demonstrated that 'distortion' is a matter of perspective, outlining a simple rule that applies to all light and a vast array of media, including underwater, optical fiber, transmission in the atmosphere and even through living biological samples. Their novel quantum approach to the problem resolves a standing debate on whether some forms of light are robust or not, correcting some misconceptions in the community.

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Quantum network nodes with warm atoms

Communication networks need nodes at which information is processed or rerouted. Physicists have now developed a network node for quantum communication networks that can store single photons in a vapor cell and pass them on later.

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New deep learning model helps the automated screening of common eye disorders

Automation in disease diagnosis is reliant on deep learning models that can accurately and efficiently identify measurements of tumors, tissue volume, or other sorts of abnormalities. Now, researchers have unveiled a new, resource-light model capable of identifying many common eye diseases.

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Sight problems may increase dementia risk in older adults

Older adults with untreated sight conditions may be at increased risk of dementia, according to a new systematic review and meta-analysis of 16 studies involving 76,373 participants.

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New deep learning model helps the automated screening of common eye disorders

Automation in disease diagnosis is reliant on deep learning models that can accurately and efficiently identify measurements of tumors, tissue volume, or other sorts of abnormalities. Now, researchers have unveiled a new, resource-light model capable of identifying many common eye diseases.

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Sight problems may increase dementia risk in older adults

Older adults with untreated sight conditions may be at increased risk of dementia, according to a new systematic review and meta-analysis of 16 studies involving 76,373 participants.

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Thursday, June 23, 2022

Listeria-based booster improves vaccine's protection against recurring colon cancer

New research in mice has paved the way for a Phase I clinical trial and has the potential to transform vaccines against HIV and malaria.

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ALS may be linked to both the immune and central nervous systems

The immune system may play a fundamental role along with the central nervous system in amyotrophic lateral sclerosis (ALS), also known as 'Lou Gehrig's disease,' researchers report.

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Climate changes lead to water imbalance, conflict in Tibetan Plateau

Climate change is putting an enormous strain on global water resources, and according to researchers, the Tibetan Plateau is suffering from a water imbalance so extreme that it could lead to an increase in international conflicts.

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Artificial photosynthesis can produce food without sunshine

Scientists have found a way to bypass the need for biological photosynthesis altogether and create food independent of sunlight by using artificial photosynthesis. The technology uses a two-step electrocatalytic process to convert carbon dioxide, electricity, and water into acetate. Food-producing organisms then consume acetate in the dark to grow. The hybrid organic-inorganic system could increase the conversion efficiency of sunlight into food, up to 18 times more efficient for some foods.

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New technology helps reveal inner workings of human genome

Researchers have developed a new method to assess on a large scale the three-dimensional structure of the human genome, or how the genome folds. The genome is the complete set of genetic instructions, DNA or RNA, enabling an organism to function.

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Silence for thought: Special interneuron networks in the human brain

Scientists map prominent differences in the neural circuits of mice, monkeys, and human.

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Humans can't, but turtles can: Reduce weakening and deterioration with age

Evolutionary theories of ageing predict that all living organisms weaken and deteriorate with age (a process known as senescence) -- and eventually die. Now, researchers show that certain animal species, such as turtles (including tortoises) may exhibit slower or even absent senescence when their living conditions improve.

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Wednesday, June 22, 2022

Optical microphone sees sound like never before

A camera system can see sound vibrations with such precision and detail that it can reconstruct the music of a single instrument in a band or orchestra. Even the most high-powered and directed microphones can't eliminate nearby sounds, ambient noise and the effect of acoustics when they capture audio. The novel system uses two cameras and a laser to sense high-speed, low-amplitude surface vibrations. These vibrations can be used to reconstruct sound, capturing isolated audio without inference or a microphone. 'We've invented a new way to see sound,' said Mark Sheinin, a post-doctoral research associate at the Illumination and Imaging Laboratory (ILIM) in the RI.

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Pushing T cells down 'memory lane' may improve cancer therapy

Scientists have identified proteins that help decide T cell fate and used the finding to improve CAR-T cell therapy in a solid tumor model.

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New understanding of congenital heart disease progression opens door to improved treatment options

Researchers have uncovered new insights into the mechanisms underlying the progression of congenital heart disease (CHD) -- a spectrum of heart defects that develop before birth and remain the leading cause of childhood death.

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Breast cancer spreads at night, study shows

A new study shows that breast cancer metastases form more efficiently while patients are sleeping. The finding could significantly change the way cancer is diagnosed and treated in future.

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Research reveals the pons plays a significant role in processing sad information

Researchers conducted studies to explain the neural mechanisms of the pons-corticolimbic network in perpetuating sad mood in depression.

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Deletion of Wt1 gene produces alterations in the reproductive organs of mice

The deletion of the Wt1 gene during the early stages of the embryonic reproductive organ formation leads to differences in sex development in adult mice, according to a new study.

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Tuesday, June 21, 2022

SeqScreen can reveal 'concerning' DNA

Computer scientists have developed a program to screen short DNA sequences, whether synthetic or natural, to determine their toxicity.

from Top Health News -- ScienceDaily https://www.sciencedaily.com/releases/2022/06/220621141746.htm

Genetic mutations enable efficient evolution of TB-causing bacteria

Researchers have identified how the bacterium that causes tuberculosis (TB) can evolve rapidly in response to new environments.

from Top Health News -- ScienceDaily https://www.sciencedaily.com/releases/2022/06/220621114712.htm

Wildlife--human conflicts could shift with climate change

Researchers modeled the risk of human -- elephant conflict in Thailand under different climate change scenarios using a risk framework. A spatial shift in the risk of conflict was observed with climate change, with northern areas and higher latitudes showing increasing risk in the future. These results can be used to develop planning strategies in affected communities and increase coexistence awareness.

from Latest Science News -- ScienceDaily https://www.sciencedaily.com/releases/2022/06/220621105629.htm

Vitamins, supplements are a 'waste of money' for most Americans

Scientists say for non-pregnant, otherwise healthy Americans, vitamins are a waste of money because there isn't enough evidence they help prevent cardiovascular disease or cancer. They've written an editorial in support of new recommendations that state there was 'insufficient evidence' that taking multivitamins, paired supplements or single supplements can help prevent cardiovascular disease and cancer in otherwise healthy, non-pregnant adults.

from Top Health News -- ScienceDaily https://www.sciencedaily.com/releases/2022/06/220621114707.htm

Sensor imperfections are perfect for forensic camera analysis

In a project aimed at developing intelligent tools to fight child exploitation, computer scientists have developed a system to analyze the noise produced by individual cameras. This information can be used to link a video or an image to a particular camera.

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Global AFib study finds simple ablation has best outcomes

Results from one of the largest global studies of atrial fibrillation (AFib) procedures show that the simple approach is usually best when it comes to ablation, a procedure where physicians destroy or ablate cardiac tissue to correct irregular heart rhythms. Researchers found that using advanced image-guided technology to more aggressively target diseased areas of the heart that cause arrythmias didn't lead to better outcomes for patients -- and put some at higher risk of strokes, according to new results.

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Monday, June 20, 2022

New model helps identify mutations that drive cancer

Scientists built a computer model that can rapidly scan the entire genome of cancer cells and identify mutations that occur more frequently than expected, suggesting that they are driving tumor growth.

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Gene discovery indicates motor neuron diseases caused by abnormal lipid processing in cells

A new genetic discovery adds weight to a theory that motor neuron degenerative diseases are caused by abnormal lipid (fat) processing pathways inside brain cells. This theory will help pave the way to new diagnostic approaches and treatments for this group of conditions. The discovery will provide answers for certain families who have previously had no diagnosis.

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A smart jumpsuit tracks infants' motor development

New wearable technology creates new possibilities for assessing the neurological development of young children. Early motor assessment is essential for supporting the early detection of neurodevelopmental problems and their therapeutic interventions.

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New effective combination therapy for pediatric T-acute leukemia

Acute lymphoblastic leukemia (ALL) is the most common cancer affecting children. The T-ALL form of leukemia that emerges from early T lineage cells has a poorer prognosis than B-lineage ALL. The prognosis for relapsed T-ALL is very poor and new therapies are sorely needed. Medical researchers have discovered a new combination of drugs that is effective against T-ALL.

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Single brain scan can diagnose Alzheimer's disease

A single MRI scan of the brain could be enough to diagnose Alzheimer's disease, according to new research.

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New effective combination therapy for pediatric T-acute leukemia

Acute lymphoblastic leukemia (ALL) is the most common cancer affecting children. The T-ALL form of leukemia that emerges from early T lineage cells has a poorer prognosis than B-lineage ALL. The prognosis for relapsed T-ALL is very poor and new therapies are sorely needed. Medical researchers have discovered a new combination of drugs that is effective against T-ALL.

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Assessing the environmental impact of nuclear power generation

A growing concern for climate change and sustainable use of natural resources has led to the adoption of alternative forms of energy. Nuclear power is considered a panacea for the environmental degradation caused by fossil fuels. However, its environmental impact and natural resource use need to be assessed. Now, researchers have addressed this issue, revealing interesting findings in their assessment of resource use for nuclear power generation.

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Saturday, June 18, 2022

Neuroscientists create maps of the brain after traumatic brain injury

Scientists have discovered that an injury to one part of the brain changes the connections between nerve cells across the entire brain.

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Neuroscientists create maps of the brain after traumatic brain injury

Scientists have discovered that an injury to one part of the brain changes the connections between nerve cells across the entire brain.

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Friday, June 17, 2022

The lasting symptoms among COVID-19 long haulers

More than two years after the COVID-19 pandemic erupted, scientists have become increasingly aware of a group of patients -- so-called 'long haulers' -- who remain plagued by a combination of symptoms long after the infection passes. In a new study, researchers describe their findings related to their multidisciplinary clinical work in this area.

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Long COVID risk less during Omicron compared to Delta, study finds

A new study finds that the Omicron variant is less likely to cause long COVID than the Delta variant.

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ADHD and ASD: What the eyes could reveal

Researchers found that recordings from the retina could identify distinct signals for both attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD), providing a potential biomarker for each condition.

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Scientists serendipitously discover rare cluster compound

Scientists at Kyoto University's Institute for Cell-Material Sciences have discovered a novel cluster compound that could prove useful as a catalyst. Compounds, called polyoxometalates, contain a large metal-oxide cluster carry a negative charge. They are found everywhere, from anti-viral medicines to rechargeable batteries and flash memory devices.

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Rethinking the rabies vaccine

Researchers may have discovered the path to better rabies vaccine design. Researchers share one of the first high-resolution looks at the rabies virus glycoprotein in its vulnerable 'trimeric' form.

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Math model predicts efficacy of drug treatments for heart attacks

Researchers used mice to develop a mathematical model of a myocardial infarction. The new model predicts several useful new drug combinations that may one day help treat heart attacks, according to researchers.

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Transparent face masks protect while facilitating communication, study finds

Commercially available transparent face masks allow for the perception of facial expressions while suppressing the dispersion of respiratory droplets that spread the SARS-CoV-2, and thus have a clear advantage over surgical face masks, a new study shows.

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ADHD and ASD: What the eyes could reveal

Researchers found that recordings from the retina could identify distinct signals for both attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD), providing a potential biomarker for each condition.

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Thursday, June 16, 2022

Wildfire smoke exposure negatively impacts dairy cow health

Increasing frequency and size of wildfires in the United States over the past several decades affect everything from human life and health to air quality, biodiversity, and land use. The US dairy industry is not exempt from these effects. The Western states, where wildfires are especially prevalent, are home to more than two million dairy cows that produce more than 25% of the nation's milk. A new report examines how dairy cattle in the Western United States may be affected by unique air pollutants from wildfire smoke.

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Targeting a specific protein in smooth muscle cells may dramatically reduce atherosclerotic plaque formation

A new study shows targeting a protein in smooth muscle cells can block and decrease buildup of atherosclerotic plaque in mouse models, according to researchers.

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Can a parasitic wasp save your fruit crops?

Researchers developed a toolkit for investigating the molecular mechanisms governing the parasitic nature of the wasp species Asobara japonica. They first used DNA and RNA-sequencing-based techniques to identify genes controlling the wasp's body color, as well as the putative toxic components in its venom. They used RNA interference to block expression of the body color gene, darkening its appearance. Future experiments will use this technique to better understand the venom components' functions.

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Scientists fail to locate once-common CA bumble bees

Several species of California bumble bees have gone missing in the first statewide census of the fuzzy pollinators in 40 years.

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New solution for stem cell manufacturing

Researchers have developed a unique 3D printed system for harvesting stem cells from bioreactors.

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Wednesday, June 15, 2022

Dog-assisted interventions lead to lower stress levels in children

Dog-assisted interventions can lead to significantly lower stress in children both with and without special needs, according to a new study using salivary cortisol levels.

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Helping middle school students achieve more

A new study of intermediate school students in urban California and New York shows promise for underachievers. Researchers found that early intervention with teachers, training students that achievement is malleable and achievable, caused struggling students to flourish and improve their grades.

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The tarantula's cosmic web: Astronomers map violent star formation in nebula outside our galaxy

Astronomers have unveiled intricate details of the star-forming region 30 Doradus, also known as the Tarantula Nebula, using new observations from the Atacama Large Millimeter/submillimeter Array (ALMA). Now we can see the nebula in a new light, with wispy gas clouds that provide insight into how massive stars shape this region.

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Helping middle school students achieve more

A new study of intermediate school students in urban California and New York shows promise for underachievers. Researchers found that early intervention with teachers, training students that achievement is malleable and achievable, caused struggling students to flourish and improve their grades.

from Top Health News -- ScienceDaily https://ift.tt/PoF3gqb

To find a planet, look for the signatures of planet formation

Finding forming planets is a tough but important job for astronomers: Only three planets have ever been discovered caught in the process of forming, and the most recent of these was found just weeks ago.

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No peers, no beers: Research shows youth substance use declined during the COVID-19 pandemic

With stay-at-home orders during the COVID-19 pandemic, youth spent more time at home with family and were more isolated from in-person interaction with peers. Largely due to this social isolation from peers, substance use among youth declined, according to researchers.

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Tuesday, June 14, 2022

DNA nanotech safe for medical use, new study suggests

Advances in nanotechnology have made it possible to fabricate structures out of DNA for use in biomedical applications like delivering drugs or creating vaccines, but new research in mice investigates the safety of the technology.

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Calculating the 'fingerprints' of molecules with artificial intelligence

With conventional methods, it is extremely time-consuming to calculate the spectral fingerprint of larger molecules. But this is a prerequisite for correctly interpreting experimentally obtained data. Now, a team has achieved very good results in significantly less time using self-learning graphical neural networks.

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Streamlining stem cells to treat macular degeneration

Scientists have tested and confirmed a protocol for growing human embryonic stem cells into retina cells to treat eye diseases such as age-related macular degeneration.

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Do our genes determine what we eat?

Preliminary findings from a new study involving more than 6,000 adults found that taste-related genes may play a role in determining food choices and could, in turn, influence cardiometabolic health.

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Most people think their diet is healthier than it is

How healthy is your diet? It seems like a simple question, but according to a new study, it's one that most Americans struggle to get right.

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New processing technique could make potatoes healthier

Researchers announced early tests of a new potato processing technique designed to make our bodies digest potato starch more slowly. Laboratory demonstrations show that the approach blocks certain digestive enzymes from reaching the potato starch as quickly, leading to a more controlled release of dietary glucose.

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Nanoparticle sensor can distinguish between viral and bacterial pneumonia

Many different types of bacteria and viruses can cause pneumonia, but there is no easy way to determine which microbe is causing a particular patient's illness. This uncertainty makes it harder for doctors to choose effective treatments because the antibiotics commonly used to treat bacterial pneumonia won't help patients with viral pneumonia. In addition, limiting the use of antibiotics is an important step toward curbing antibiotic resistance.

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Monday, June 13, 2022

Good news on blocking a virus considered a global threat

Scientists have reported good news on the pandemic preparedness front: A cocktail of four manufactured antibodies is effective at neutralizing a virus from the Henipavirus family, a group of pathogens considered to be a global biosecurity threat.

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Children in remote school faced more sleep, behavior and social challenges

Elementary school-aged children enrolled in remote learning experienced greater behavioral, learning-related, and sleep difficulties compared with children receiving in-person instruction, according to the findings of a new study.

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Research reveals the science behind this plant's blue berries

A new study confirms Lantana strigocamara as the second-ever documented case of a plant creating blue-colored fruits with layered fat molecules.

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Can they make graphite from coal? Researchers start by finding new carbon solid

As the world's appetite for carbon-based materials like graphite increases, researchers presented evidence this week for a new carbon solid they named 'amorphous graphite.'

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Are we born with a moral compass?

Researchers found that preverbal infants can make and act on moral judgments about antisocial behavior in a third party. Using a new cognitive paradigm with gaze tracking, researchers were able to show that 8-month-old infants can engage in third-party punishment. This indicates that humans may have acquired morality through evolution, and opens the door for future experiments to investigate unexplored elements of infant cognition.

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Children in remote school faced more sleep, behavior and social challenges

Elementary school-aged children enrolled in remote learning experienced greater behavioral, learning-related, and sleep difficulties compared with children receiving in-person instruction, according to the findings of a new study.

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Friday, June 10, 2022

Binge drinking raises risk of developing alcohol problems, even for moderate drinkers

Moderate average drinkers with a pattern of binge drinking were almost five times more likely to experience multiple alcohol problems, researchers report.

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Higher rate of COVID-19 death before vaccination linked to certain common inflammatory immune conditions

People with certain inflammatory immune conditions affecting the joints, bowel and skin, such as rheumatoid arthritis, may have been more at risk of dying or needing hospital care if they got COVID-19 before vaccination compared with the general population, according to a new study.

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Dogs inhale immunotherapy to test lung cancer treatment

An inhaled immunotherapy successfully treated cancer in some companion dogs as part of a clinical trial conducted by oncology and veterinary researchers. Results show potential for fighting cancer in humans as well.

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Existing cancer therapy in narrow use shows significant activity against other cancers

A drug currently used in just 1% of cancers has significant potential against the remaining 99%, according to a new study. Ivosidenib, or AG-120, is currently used against cancers that have a mutation in the IDH1 gene. However, study results show that Ivosidenib is also effective against unmutated, or 'wild-type' IDH1. The protein coded by the IDH1 gene in cancers helps cancer cells survive in a stressful tumor environment, so any inhibitor medication that could weaken this defense mechanism is considered a promising therapy.

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Dogs inhale immunotherapy to test lung cancer treatment

An inhaled immunotherapy successfully treated cancer in some companion dogs as part of a clinical trial conducted by oncology and veterinary researchers. Results show potential for fighting cancer in humans as well.

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Existing cancer therapy in narrow use shows significant activity against other cancers

A drug currently used in just 1% of cancers has significant potential against the remaining 99%, according to a new study. Ivosidenib, or AG-120, is currently used against cancers that have a mutation in the IDH1 gene. However, study results show that Ivosidenib is also effective against unmutated, or 'wild-type' IDH1. The protein coded by the IDH1 gene in cancers helps cancer cells survive in a stressful tumor environment, so any inhibitor medication that could weaken this defense mechanism is considered a promising therapy.

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Thursday, June 9, 2022

Pre-historic Wallacea: A melting pot of human genetic ancestries

The Wallacean islands of present-day Eastern Indonesia have a long history of occupation by modern humans. Notably, the maritime expansion of Austronesian speakers into Wallacea left archaeological traces of a Neolithic lifestyle and a genetic imprint still detectable in Eastern Indonesians today. To gain further insights into Wallacea's settlement history, scientists sequenced and analyzed sixteen ancient genomes from different islands of Wallacea, finding evidence for repeated genetic admixtures starting at least 3,000 years ago.

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New study paves way to better understand and treat those suffering from long COVID

A new study links SARS-CoV-2 specific T cells to lung function and those who suffer from long-term COVID symptoms (PASC).

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Heavy drinkers four times more likely to smoke in England, study finds

Those who are among the heaviest drinkers in England are four times more likely to smoke than the general population and should be prioritized by the government in its plans to achieve 'smoke-free' status by 2030, experts say.

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'Fantastic giant tortoise,' believed extinct, confirmed alive in the Galápagos

A tortoise from a Galápagos species long believed extinct has been found alive. Fernanda, named after her Fernandina Island home, is the first of her species identified in more than a century. Geneticist successfully extracted DNA from a specimen collected from the same island more than a century ago and confirmed that Fernanda and the museum specimen are members of the same species and genetically distinct from all other Galápagos tortoises.

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Antarctic glaciers losing ice at fastest rate for 5,500 years

New evidence suggests that two major glaciers in the West Antarctic Ice Sheet (WAIS) are losing ice at the fastest rate for at least 5,500 years.

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New study paves way to better understand and treat those suffering from long COVID

A new study links SARS-CoV-2 specific T cells to lung function and those who suffer from long-term COVID symptoms (PASC).

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Heavy drinkers four times more likely to smoke in England, study finds

Those who are among the heaviest drinkers in England are four times more likely to smoke than the general population and should be prioritized by the government in its plans to achieve 'smoke-free' status by 2030, experts say.

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Wednesday, June 8, 2022

Climate change and human exploitation to blame for historic decline in Atlantic Salmon

Research has revealed that an abrupt change in climate conditions in the North Atlantic around 800 years ago played a role in a decline in Atlantic salmon populations returning to rivers. Subsequent human exploitation of salmon combined to reduce their populations still further.

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Rapid Ebola diagnosis may be possible with new technology

A new tool can quickly and reliably identify the presence of Ebola virus in blood samples, according to a new study. The technology, which uses so-called optical microring resonators, potentially could be developed into a rapid diagnostic test for the deadly Ebola virus disease, which kills up to 89% of infected people.

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Amazon River freshwater fish show signs of overexploitation

As the cherished rainforest in South America's Amazon River region continues to shrink, the river itself now presents evidence of other dangers: the overexploitation of freshwater fish.

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New delivery method allows slow-release of broader array of peptide drugs in the body

A new study describes one of the first entirely new drug delivery microencapsulation approaches in decades.

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Pregnant women's drinking correlates with their partner's drinking

Pregnant women's use of alcohol correlates with that of their partner, a new study shows. Paying attention to both parents' use of alcohol may help to prevent drinking during pregnancy, as well as fetal exposure to the adverse effects of alcohol.

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Three distinct brain circuits in the thalamus contribute to Parkinson's symptoms

Neuroscientists identified three circuits in the thalamus that influence the development of motor and nonmotor symptoms of Parkinson's disease. And by manipulating these circuits, they could reverse Parkinson's symptoms in mice.

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Tuesday, June 7, 2022

How genetics influence immunity in patients with type 1 diabetes

Scientists have characterized the genetic factors that affect the immune response in type 1 diabetes patients, with potential implications for developing new treatments.

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Deep nerve stimulation consistently reduces blood pressure

Biomedical engineers are expanding the study of wireless electrodes to treat hypertension and are reporting that blood pressure can be consistently controlled by bioelectronic treatment.

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How fast-growing bacteria can resist antibiotics

New insights into how some bacteria survive antibiotics could lead to the development of novel treatment strategies.

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Low levels of high-risk salmonella evade traditional methods of detection

Poultry is responsible for more than one out of every five cases of salmonella infection in the U.S. But traditional methods of testing the chicken you grab off the grocery shelf may not be enough to detect all strains of the bacteria, according to new research.

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How mothers calm their distressed infants with soothing signals

This study demonstrates empirically, for the first time, that synchronized physiology between mothers and babies plays a role in soothing distressed infants, and that treating postpartum depression with cognitive behavioral therapy can improve the synchronicity patterns and thereby augment mothers' ability to soothe their distressed babies.

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Neuroscientists identify role of basolateral amygdala neurons

The basolateral amygdala (BLA) is a region of the brain that has been almost exclusively studied in the context of fear and emotion. Only recently have researchers begun to question whether the BLA may play a larger, overarching role in memory and behavior. Yet almost nothing is known about the neuronal activity of the BLA during naturalistic behavior. To address these questions, neuroscientists at the Sainsbury Wellcome Centre at UCL observed the neuronal activity in this brain region while rats freely engaged with a variety of different ethological stimuli.  Interactions with ethological stimuli are relevant to the animal's survival and to the propagation of its genes, and include food, prey and conspecifics. In a new study, published today in Cell Reports, the researchers demonstrate strong responses to these classes of events in the BLA.

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Deep nerve stimulation consistently reduces blood pressure

Biomedical engineers are expanding the study of wireless electrodes to treat hypertension and are reporting that blood pressure can be consistently controlled by bioelectronic treatment.

from Top Health News -- ScienceDaily https://ift.tt/0sI3YEM

Monday, June 6, 2022

Body versus brain: New evidence for an autoimmune cause of schizophrenia

Researchers have found that some people with schizophrenia have autoantibodies -- which are made by the immune system and recognize the body's own proteins, rather than outside threats such as viruses or bacteria -- against NCAM1, a protein that's important for communication between brain cells. The patients' autoantibodies also caused schizophrenia-related behaviors in mice. These findings may improve the diagnosis and treatment of a subset of patients with schizophrenia.

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New way to identify influenza A virus lights up when specific virus targets are present

In order to quickly detect the presence of the influenza A virus, researchers developed a fluorogenic probe that could bind to the promoter region. A fluorogenic probe uses tiny molecules called fluorophores that emit light when a specific target is present.

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Power up: New polymer property could boost accessible solar power

Researchers have observed structural chirality, a biological property important to photosynthesis, emerging in achiral conjugated polymers. Their discovery could help enhance flexible solar cell design and increase access to affordable renewable energy.

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Novel method for early disease detection using DNA droplets

Droplet systems such as DNA droplets, which are formed by liquid-liquid phase separation of macromolecules, play an essential role in cellular functions. Now, by combining the technologies of DNA droplets and DNA computing, computational DNA droplets have been developed, which can recognize specific patterns in tumor biomarker microRNA sequences.

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Novel method for early disease detection using DNA droplets

Droplet systems such as DNA droplets, which are formed by liquid-liquid phase separation of macromolecules, play an essential role in cellular functions. Now, by combining the technologies of DNA droplets and DNA computing, computational DNA droplets have been developed, which can recognize specific patterns in tumor biomarker microRNA sequences.

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Removing barriers to opioid use disorder treatment shows success during pandemic

Pandemic-era changes to prescribing guidelines for the lifesaving drug buprenorphine led to improved treatment outcomes for patients with opioid use disorder in Philadelphia, according to a recently published study.

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Removing barriers to opioid use disorder treatment shows success during pandemic

Pandemic-era changes to prescribing guidelines for the lifesaving drug buprenorphine led to improved treatment outcomes for patients with opioid use disorder in Philadelphia, according to a recently published study.

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Sunday, June 5, 2022

Promising rectal cancer study

A scientist comments on the evolving treatment of rectal cancer in light of findings from a study that found the immunotherapy drug dostarlimab was especially effective in a phase II clinical trial of a dozen patients with a subtype of rectal cancer.

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Promising rectal cancer study

A scientist comments on the evolving treatment of rectal cancer in light of findings from a study that found the immunotherapy drug dostarlimab was especially effective in a phase II clinical trial of a dozen patients with a subtype of rectal cancer.

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Saturday, June 4, 2022

Some blood pressure medicine may decrease the aneurysm rupture risk for people with high blood pressure

A new study has found that RAAS inhibitors, a class of blood pressure-lowering medicine, may be better at reducing the risk of brain aneurysm rupture. People with a brain aneurysm -- a weakened area of a blood vessel -- who were being treated for high blood pressure with medication from the class of drugs called RAAS inhibitors had a significantly lower risk of a ruptured aneurysm compared to those who took other blood pressure medications. These results indicate that RAAS inhibitors may be preferable to other blood pressure-lowering medications and could inform treatment decisions for people with high blood pressure who have unruptured intracranial aneurysms.

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This parasite will self-destruct: Researchers discover new weapon against drug-resistant malaria

A new method to combat malaria which sees the disease turn against itself could offer an effective treatment for the hundreds of millions of people infected globally each year, as the efficacy of current antimalarial drugs weakens. The research has identified an anti-malarial compound, ML901, which inhibits the malaria parasite but does not harm mammalian -- human or other mammals' -- cells.

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Friday, June 3, 2022

Ibrutinib with chemoimmunotherapy improved progression-free survival for newly diagnosed mantle cell lymphoma patients

Combination chemoimmunotherapy with the Bruton's tyrosine kinase (BTK) inhibitor ibrutinib demonstrated improved progression-free survival over standard chemoimmunotherapy for previously untreated mantle cell lymphoma (MCL) in patients 65 and over, researchers reported.

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Ibrutinib with chemoimmunotherapy improved progression-free survival for newly diagnosed mantle cell lymphoma patients

Combination chemoimmunotherapy with the Bruton's tyrosine kinase (BTK) inhibitor ibrutinib demonstrated improved progression-free survival over standard chemoimmunotherapy for previously untreated mantle cell lymphoma (MCL) in patients 65 and over, researchers reported.

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A digital twin for citrus fruits

Around one third of all food worldwide ends up in the trash bin instead of on our plate. With the help of digital twins, researchers at Empa and Stellenbosch University are now aiming to reduce food waste, for example in the case of citrus fruits, along the production and supply chains. The hygrothermal measurement data needed to improve the shelf life of oranges and the like would actually be available. So far, however, they have been underutilized, the researchers write in a recent study in the journal Nature Food.

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Promising compound kills range of hard-to-treat cancers by targeting a previously undiscovered vulnerability

A compound called ERX-41 targets a previously unrecognized vulnerability in difficult-to-treat types of cancer including triple-negative breast cancer. The compound will be studied as a drug for clinical translation.

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Primates and non-primates differ in the architecture of their neurons

High-resolution microscopy now enabled an international research team to enlarge the knowledge about species-specific differences of the architecture of cortical neurons.

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Promising compound kills range of hard-to-treat cancers by targeting a previously undiscovered vulnerability

A compound called ERX-41 targets a previously unrecognized vulnerability in difficult-to-treat types of cancer including triple-negative breast cancer. The compound will be studied as a drug for clinical translation.

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Thursday, June 2, 2022

Height may be risk factor for multiple health conditions

A large genetic study has found that a person's height may affect their risk for several common health conditions in adulthood. Significant findings include a link between height and lower risk of coronary heart disease, and a link between height and higher risk for peripheral neuropathy and circulatory disorders.

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Immune therapy targets cells that cause leukemia relapse

Genetically engineered immune cells successfully target the specific cancer cells that may be responsible for relapse of acute myeloid leukemia (AML), a type of blood cancer, and proved effective in animal models of the disease, according to a preclinical study. The new cell therapy, now being tested in phase 1 clinical trials, may ultimately help patients with AML to remain cancer-free.

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Joining the fight against non-small cell lung cancer

Scientists develop a blood test that could help with early detection of non-small cell lung cancer, as well as potential drug resistance.

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Study finds fecal microbiota transplantation to be cost effective treatment for any recurrent Clostridiodes Difficile infection

Medical researchers have found that Fecal Microbiota Transplantation, or FMT, is an optimal cost-effective treatment for first recurrent Clostridioides difficile infection.

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New discoveries in lupus research

A national expert in systemic lupus erythematosus, or lupus, at the University of Houston has identified biomarkers for heart disease and for children with lupus nephritis.

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Benefit of supplements for slowing age-related macular degeneration

The AREDS2 dietary supplement formula not only reduces risk of lung cancer due to beta-carotene, but is also more effective at reducing risk of AMD progression, compared to the original AREDS formula.

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Immune therapy targets cells that cause leukemia relapse

Genetically engineered immune cells successfully target the specific cancer cells that may be responsible for relapse of acute myeloid leukemia (AML), a type of blood cancer, and proved effective in animal models of the disease, according to a preclinical study. The new cell therapy, now being tested in phase 1 clinical trials, may ultimately help patients with AML to remain cancer-free.

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Wednesday, June 1, 2022

Combination anti-HIV antibody infusions suppress virus for prolonged period

Individuals with HIV who began taking antiretroviral therapy (ART) in the early stages of infection achieved a lengthy period of HIV suppression without ART after receiving two broadly neutralizing anti-HIV antibodies (bNAbs), according to a small study. The findings suggest that combination bNAb therapy might offer a future alternative to daily ART for people living with HIV.

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Age-related lung changes provide pathway for metastatic growth of dormant melanoma cancer cells

New laboratory research finds that secreted age-induced changes in distant sites such as the lung can effectively reactivate dormant cells and cause them to grow.

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Age-related lung changes provide pathway for metastatic growth of dormant melanoma cancer cells

New laboratory research finds that secreted age-induced changes in distant sites such as the lung can effectively reactivate dormant cells and cause them to grow.

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New tool helps older adults monitor 'attentional performance' during driving

Researchers have developed a straightforward questionnaire that older adults can use to assess their 'attentional performance' during driving. In proof-of-concept testing, the researchers have demonstrated the tool can predict which drivers are at increased risk of having accidents.

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A 'Goldilocks amount' of time spent online could be good for teenagers' wellbeing

New research has found further evidence of a relationship between online engagement and mental wellbeing in teenagers. The study contributes to mounting international evidence on the dangers of high levels of digital media use.

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Forests: Spatial aspects of biodiversity, homogenization threat to forest ecosystems

A study highlights the importance of spatial aspects of biodiversity for healthy functioning of naturally occurring forests. Biologists determined that tree beta diversity -- a measure of site-to-site variation in the composition of species present within a given area -- matters more for ecosystem functioning than other components of biodiversity at larger scales. The research also shows that the relationship between beta diversity and tree biomass strengthens with increasing spatial scale (the size of an area) a finding that has implications for conservation planning.

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New tool helps older adults monitor 'attentional performance' during driving

Researchers have developed a straightforward questionnaire that older adults can use to assess their 'attentional performance' during driving. In proof-of-concept testing, the researchers have demonstrated the tool can predict which drivers are at increased risk of having accidents.

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Only 13 % know: The one-minute self-exam that could save young men’s lives

A new survey shows most Americans wrongly think testicular cancer is an older man's issue, despite it most commonly affecting men aged 2...