Scientists shut down cancer DNA repair to overcome drug resistance

Cancer cells often survive treatment by fixing the DNA damage that therapy is meant to cause. Researchers found that UNI418 can disrupt this repair ability, leaving cancer cells more exposed. When combined with a PARP inhibitor, it helped resistant cancer cells respond to treatment again. The findings point to a new strategy for overcoming cancer drug resistance.

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Scientists shut down cancer DNA repair to overcome drug resistance

Cancer cells often survive treatment by fixing the DNA damage that therapy is meant to cause. Researchers found that UNI418 can disrupt this repair ability, leaving cancer cells more exposed. When combined with a PARP inhibitor, it helped resistant cancer cells respond to treatment again. The findings point to a new strategy for overcoming cancer drug resistance.

from Top Health News -- ScienceDaily https://ift.tt/U4QZvIw

Sleep apnea’s hidden heart disease trigger found in the gut

A surprising gut-heart connection may help explain why sleep apnea increases the risk of cardiovascular disease. In mice, disabling a bile acid receptor called FXR sharply reduced plaque buildup, opening the door to potential new treatments based on gut microbes and their chemical signals.

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Scientists found a new Alzheimer’s trigger and a drug that stops it

Researchers have identified a new Alzheimer’s target and created an experimental compound that blocks a damaging process inside brain cells. In mice, the treatment slowed nerve cell loss, reduced Alzheimer’s-related changes, and even appeared to promote healthier aging.

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Scientists found a new Alzheimer’s trigger and a drug that stops it

Researchers have identified a new Alzheimer’s target and created an experimental compound that blocks a damaging process inside brain cells. In mice, the treatment slowed nerve cell loss, reduced Alzheimer’s-related changes, and even appeared to promote healthier aging.

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Heat breaks the rules at the nanoscale and scientists used it to their advantage

Scientists used nanoscale gold metamaterials to supercharge heat transfer across tiny gaps, achieving up to four times more energy flow than similar conventional systems. The breakthrough could lead to better chip cooling, more efficient energy technologies, and a new era of precision heat engineering.

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Doctors thought this kidney drug helped some patients. It may help millions more.

A trio of major studies found that finerenone may protect the kidneys and heart in far more people than previously thought. The drug significantly slowed kidney disease progression and reduced the risks of kidney failure, heart failure, cardiovascular death, and overall mortality. Researchers saw benefits not only in patients with diabetes but also in those with non-diabetic kidney disease, a group with limited treatment options.

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