Combination therapy with Rapamycin and Trametinib prolongs the life of mice

Researchers have discovered that the combination of the two cancer drugs Rapamycin and Trametinib significantly extends the lifespan of mice. This therapy shows greater effects than the individual drugs and offers not only a longer lifespan, but also health benefits in old age. The results suggest that this drug combination could be a promising strategy for combating age-related diseases and promoting longevity.

from Top Health News -- ScienceDaily https://ift.tt/duPmynL

Genetic deep dive dispels fear of hybrid worm threat

Parasitic worms that infect humans are not interbreeding with those that infect cattle as previously thought. This is good news for when it comes to controlling schistosomiasis, a disease caused by these worms that affects more than 200 million people globally.

from Top Health News -- ScienceDaily https://ift.tt/EiZmd1y

A high-fat diet sets off metabolic dysfunction in cells, leading to weight gain

Researchers find high-fat diets set off metabolic dysfunction in cells, leading to weight gain, but these effects can be reversed by treatment with an antioxidant.

from Top Health News -- ScienceDaily https://ift.tt/bUmfSTu

Chemists recreate how RNA might have reproduced for first time

Chemists have demonstrated how RNA (ribonucleic acid) might have replicated itself on early Earth -- a key process in the origin of life.

from Latest Science News -- ScienceDaily https://ift.tt/GnqT8HW

Even birds can't outfly climate change

As rising global temperatures alter ecosystems worldwide, animal species usually have two choices: adapt to changing local conditions or flee to a cooler clime. Ecologists have long assumed that the world's bird species were best equipped to respond to the pressures of climate change simply because they have the option of flying to higher altitudes or towards global poles. But a new study finds that few bird species are able to escape the realities of a warming world.

from Latest Science News -- ScienceDaily https://ift.tt/ahoIirv

Newly discovered 'molecular fingerprints' could transform diabetes treatment and diagnosis

Researchers reveal unprecedented insights into insulin resistance that could pave the way for better treatments and earlier detection of type 2 diabetes.

from Top Health News -- ScienceDaily https://ift.tt/o9VmnC1

Oldest whale bone tools discovered

Humans were making tools from whale bones as far back as 20,000 years ago, according to a new study. This discovery broadens our understanding of early human use of whale remains and offers valuable insight into the marine ecology of the time.

from Latest Science News -- ScienceDaily https://ift.tt/RUPLAif

Weight loss linked to nerve cells in the brain

A specific group of nerve cells in the brain stem appears to control how semaglutide affects appetite and weight -- without causing nausea.

from Latest Science News -- ScienceDaily https://ift.tt/DLTYyEg

Weight loss linked to nerve cells in the brain

A specific group of nerve cells in the brain stem appears to control how semaglutide affects appetite and weight -- without causing nausea.

from Top Health News -- ScienceDaily https://ift.tt/DLTYyEg

Antidepressant withdrawal symptoms more common among long-term users

People who have been taking antidepressants for more than two years are substantially more likely to experience withdrawal symptoms compared to short-term users when they come off the medication, finds a new study.

from Top Health News -- ScienceDaily https://ift.tt/ABVZoKp

Digital mental health tools need human touch

Keeping a human in the loop significantly enhances emotional engagement during online psychological interviews.

from Top Health News -- ScienceDaily https://ift.tt/ZLQMC60

Oxygen deprivation promotes colon cancer growth

Researchers found that the Wnt5a protein, secreted by inflammatory fibroblasts within cancerous tumors, inhibits angiogenesis and consequently promotes hypoxia within tumors. Hypoxic conditions help sustain the inflammatory fibroblasts, which also secrete the growth factor epiregulin, thereby promoting tumor growth. This newly proposed mechanism for tumor growth offers a promising new target for cancer therapies and possibly other conditions linked to inflammation, such as inflammatory bowel disease.

from Top Health News -- ScienceDaily https://ift.tt/B4oFLgh

Southeast Asia could prevent up to 36,000 ozone-related early deaths a year by 2050 with stricter air pollution controls

A study has found that implementing robust air pollution control measures could mean Southeast Asian countries prevent as many as 36,000 ozone-related premature deaths each year by 2050.

from Top Health News -- ScienceDaily https://ift.tt/BmyCNft

A leap forward in transparent antimicrobial coatings

Hydrogen boride (HB) nanosheets can inactivate viruses, bacteria, and fungi within minutes in the dark conditions. By coating surfaces with HB nanosheets, it rapidly inactivates SARS-CoV-2, influenza virus, and other pathogens. The nanosheets work by denaturing microbial proteins, offering a safe, effective, and versatile antimicrobial coating for everyday items.

from Top Health News -- ScienceDaily https://ift.tt/hGLS5WD

PREVENT equation accurately estimated 10-year CVD risk and those with calcium buildup

A new risk calculator accurately identified participants who had calcium buildup in their heart arteries and those who had a higher future heart attack risk, in an analysis of about 7,000 adults in New York City referred for heart disease screening.

from Latest Science News -- ScienceDaily https://ift.tt/YQhkGet

PREVENT equation accurately estimated 10-year CVD risk and those with calcium buildup

A new risk calculator accurately identified participants who had calcium buildup in their heart arteries and those who had a higher future heart attack risk, in an analysis of about 7,000 adults in New York City referred for heart disease screening.

from Top Health News -- ScienceDaily https://ift.tt/YQhkGet

New atom-swapping method applied to complex organic structures

Chemists have developed an efficient skeletal editing method for frequently used heteroaromatic structures. The technique could serve as a means to chemically modify biologically active compounds.

from Latest Science News -- ScienceDaily https://ift.tt/4R7l2Kx

Climate change poses severe threat to bowhead whale habitat

New research examining 11,700 years of bowhead whale persistence throughout the Arctic projects that sea ice loss due to climate change will cause their habitat to severely contract by up to 75 per cent.

from Latest Science News -- ScienceDaily https://ift.tt/qSov3P6

ALMA measures evolution of monster barred spiral galaxy

Astronomers have observed a massive and extremely active barred spiral galaxy in the early Universe and found that it has important similarities and differences with modern galaxies. This improves our understanding of how barred spiral galaxies, like our own Milky Way Galaxy, grow and evolve.

from Latest Science News -- ScienceDaily https://ift.tt/vmcACGY

Unlocking the secrets of bat immunity

Bats are known as natural hosts for highly pathogenic viruses such as MERS- and SARS-related coronaviruses, as well as the Marburg and Nipah viruses. In contrast to the severe and often fatal disease outcomes these viruses cause in humans, bats generally do not show obvious signs of viral illness following infection. An international research team has developed an innovative organoid research platform that allowed them to closely investigate the cellular antiviral defense mechanisms of mucosal epithelial tissues of bats. The results could pave the way for the development of new therapies against viral diseases.

from Latest Science News -- ScienceDaily https://ift.tt/OlmYJ8B

Cover crops may not be solution for both crop yield, carbon sequestration

People have assumed climate change solutions that sequester carbon from the air into soils will also benefit crop yields. But a new study finds that most regenerative farming practices to build soil organic carbon -- such as planting cover crops, leaving stems and leaves on the ground and not tilling -- actually reduce yields in many situations.

from Latest Science News -- ScienceDaily https://ift.tt/3MDh0et

Eating craved foods with meals lessens cravings, boosts weight loss

Small clinical study with obese dieters who had chronic health problems found that eating balanced meals and including craved foods with those meals helped dieters manage cravings, even into the yearlong maintenance phase of the program.

from Top Health News -- ScienceDaily https://ift.tt/aJxA3es

Invisible currents at the edge: Research team shows how magnetic particles reveal a hidden rule of nature

If you've ever watched a flock of birds move in perfect unison or seen ripples travel across a pond, you've witnessed nature's remarkable ability to coordinate motion. Recently, a team of scientists and engineers has discovered a similar phenomenon on a microscopic scale, where tiny magnetic particles driven by rotating fields spontaneously move along the edges of clusters driven by invisible 'edge currents' that follow the rules of an unexpected branch of physics.

from Latest Science News -- ScienceDaily https://ift.tt/kE1yQ9C

Experimental painkiller could outsmart opioids -- without the high

A study shows a non-opioid pain reliever blocks pain at its source -- calming specific nerve signals that send pain messages to the brain. In mice, the compound SBI-810 eased pain from surgery, bone fractures, and nerve injury without causing sedation or constipation.

from Top Health News -- ScienceDaily https://ift.tt/6W2Ujd5

Recessive genes are subject to Darwinian selection

As a group, carriers of recessive disorders are slightly less healthy and have a reduced chance of having offspring. This disadvantage is greatest for carriers of a recessive gene for intellectual disability, and reflected in a shorter school career and increased childlessness, according to new research. Time to rewrite the textbooks?

from Top Health News -- ScienceDaily https://ift.tt/2oLD4Bl

Particles carrying multiple vaccine doses could reduce the need for follow-up shots

New polymer microparticles can be used to deliver vaccines at different times. The work could lead to childhood vaccines given just once, eliminating the need for booster doses.

from Latest Science News -- ScienceDaily https://ift.tt/dMERLae

Particles carrying multiple vaccine doses could reduce the need for follow-up shots

New polymer microparticles can be used to deliver vaccines at different times. The work could lead to childhood vaccines given just once, eliminating the need for booster doses.

from Top Health News -- ScienceDaily https://ift.tt/dMERLae

New catalyst boosts efficiency of CO2 conversion

Researchers have developed an encapsulated cobalt-nickel alloy that significantly improves the efficiency and durability of high-temperature CO2 conversion, a promising technology for carbon recycling and sustainable fuel production.

from Latest Science News -- ScienceDaily https://ift.tt/hFR0kpa

With AI, researchers predict the location of virtually any protein within a human cell

Researchers developed a new machine learning method that, given a relevant amino acid sequence, can automatically predict the location of a protein in any human cell line down to the single-cell level. This advance could help clinicians identify certain diseases, streamline the process of drug discovery, and give biologists new insights into the effects of protein mutations.

from Top Health News -- ScienceDaily https://ift.tt/dFJEP4O

An ink that boosts coral reef settlement by 20 times

With coral reefs in crisis due to climate change, scientists have engineered a bio-ink that could help promote coral larvae settlement and restore these underwater ecosystems before it's too late. Researchers demonstrate that the ink could boost coral settlement by more than 20 times, which they hope could contribute to rebuilding coral reefs around the world.

from Latest Science News -- ScienceDaily https://ift.tt/zsr7XB3

Making connections: A three-dimensional visualization of musculoskeletal development

Using a new fluorescent mouse model with advanced imaging techniques, researchers have successfully visualized how musculoskeletal components are integrated into the functional locomotor system during embryonic development.

from Top Health News -- ScienceDaily https://ift.tt/gYXN6nq

Why are urban children more prone to allergies?

Evidence of a unique T cell may explain why urban children are more prone to allergies than rural children. Differences in the development of the gut microbiome may be an underlying cause.

from Top Health News -- ScienceDaily https://ift.tt/zLtnAeJ

Combinations of chronic illnesses could double risk of depression

People with multiple long-term physical health conditions are at a significantly greater risk of developing depression, a study shows.

from Top Health News -- ScienceDaily https://ift.tt/j7GDh2u

Astrophysicist searches for ripples in space and time in new way

Massive ripples in the very fabric of space and time wash over Earth constantly, although you'd never notice. An astrophysicist is trying a new search for these gravitational waves.

from Latest Science News -- ScienceDaily https://ift.tt/tJzXd2v

Is AI truly creative? Turns out creativity is in the eye of the beholder

What makes people think an AI system is creative? New research shows that it depends on how much they see of the creative act. The findings have implications for how we research and design creative AI systems, and they also raise fundamental questions about how we perceive creativity in other people.

from Top Health News -- ScienceDaily https://ift.tt/b0fjJnk

The how and why of the brain's division across hemispheres

Why does the brain split visual spatial perception between its hemispheres? A new review by neuroscientists examines the advantages and trade-offs, and how the brain ultimately makes vision feel seamless.

from Latest Science News -- ScienceDaily https://ift.tt/XCPZv5D

Fat-rich fluid fuels immune failure in ovarian cancer

New research has uncovered how lipid-rich fluid in the abdomen, known as ascites, plays a central role in weakening the body's immune response in advanced ovarian cancer. The findings offer new insights into immune suppression in ovarian cancer and open promising avenues for future immunotherapy approaches. Over 70% of patients with ovarian cancer are diagnosed at an advanced stage, often presenting with large volumes of ascites. This ascites fluid not only supports the spread of cancer throughout the abdominal cavity but also significantly impairs the body's immune defenses. Understanding how ascites affects the immune system is important for developing better treatments that use the immune system to fight cancer.

from Top Health News -- ScienceDaily https://ift.tt/0pHCKiM

Fat-rich fluid fuels immune failure in ovarian cancer

New research has uncovered how lipid-rich fluid in the abdomen, known as ascites, plays a central role in weakening the body's immune response in advanced ovarian cancer. The findings offer new insights into immune suppression in ovarian cancer and open promising avenues for future immunotherapy approaches. Over 70% of patients with ovarian cancer are diagnosed at an advanced stage, often presenting with large volumes of ascites. This ascites fluid not only supports the spread of cancer throughout the abdominal cavity but also significantly impairs the body's immune defenses. Understanding how ascites affects the immune system is important for developing better treatments that use the immune system to fight cancer.

from Latest Science News -- ScienceDaily https://ift.tt/0pHCKiM

New study traces sharp regional shifts in ischemic heart disease burden -- a global warning signal

A new study puts the spotlight on the rising burden of ischemic heart disease across Southeast Asia, East Asia and Oceania, and calls for localized, equity-focused interventions in these regions. The researchers identified region-specific, modifiable risk factors that influence the increasing prevalence of ischemic heart disease, such as toxic air pollution in East Asia and ultra-processed dietary dependence in Oceania.

from Latest Science News -- ScienceDaily https://ift.tt/MHAiUyC

Enhanced CAR T cell therapy offers new strategy for lymphoma

A phase I study of a next-generation CAR T cell therapy showed a 52 percent complete remission rate for patients with relapsed/refractory lymphoma.

from Latest Science News -- ScienceDaily https://ift.tt/pto7C5h

Enhanced CAR T cell therapy offers new strategy for lymphoma

A phase I study of a next-generation CAR T cell therapy showed a 52 percent complete remission rate for patients with relapsed/refractory lymphoma.

from Top Health News -- ScienceDaily https://ift.tt/pto7C5h

Cracking the code: Deciphering how concrete can heal itself

Lichen is an understated presence in our everyday world, often found clinging to trees and rocks. Its true beauty lies in its unique symbiotic system of fungi and algae, or cyanobacteria, that form a self-sustaining partnership, allowing it to thrive in even the harshest conditions. With that inspiration, researchers created a synthetic lichen system that collaborates like natural lichens. Their system uses cyanobacteria, which turns air and sunlight into food, and filamentous fungi, which produces minerals that seal the cracks. Working together, these microbes survive on nothing more than air, light and water. The autonomy of this system sets it apart from previous self-healing concrete endeavors.

from Latest Science News -- ScienceDaily https://ift.tt/20vsNFA

Birds form bonds that look a lot like friendship

A study of starlings in Africa shows that they form long-term social bonds similar to human friendships.

from Top Health News -- ScienceDaily https://ift.tt/VW6dlKf

Most people say they want to know their risk for Alzheimer's dementia, fewer follow through

A new study examines the choices healthy research volunteers make when given the opportunity to learn their risk of developing Alzheimer's disease dementia. The researchers found a large discrepancy between the percentage of participants who said they would like to learn their risk if such estimates became available and the percentage who followed through to learn those results when given the actual opportunity.

from Top Health News -- ScienceDaily https://ift.tt/vkgHf7L

AI could help improve early detection of interval breast cancers

A new study suggests that artificial intelligence (AI) could help detect interval breast cancers before they become more advanced and harder to treat.

from Top Health News -- ScienceDaily https://ift.tt/7ewoWZg

Artificial oxygen supply in coastal waters: A hope with risks

Could the artificial introduction of oxygen revitalise dying coastal waters? While oxygenation approaches have already been proven successful in lakes, their potential side effects must be carefully analysed before they can be used in the sea. This is the conclusion of researchers from GEOMAR Helmholtz Centre for Ocean Research Kiel and Radboud University in the Netherlands. In an article in the scientific journal EOS, they warn: Technical measures can mitigate damage temporarily and locally, but they are associated with considerable uncertainties and risks. Above all, they do not offer a permanent solution because the oxygen content will return to its previous level once the measures end, unless the underlying causes of the problem, nutrient inputs and global warming, are not tackled.

from Latest Science News -- ScienceDaily https://ift.tt/ug6C1dB

Designer microbe shows promise for reducing mercury absorption from seafood

Scientists inserted DNA-encoding methylmercury detoxification enzymes into the genome of an abundant human gut bacterium. The engineered bacterium detoxified methylmercury in the gut of mice and dramatically reduced the amount that reached other tissues, such as the brain and liver. Mice given an oral probiotic containing the engineered microbe and fed a diet high in bluefin tuna had much lower methylmercury levels than expected, suggesting that a probiotic might eventually make it safer for people to consume fish. Researchers performed the tests using pregnant mice and found lower levels of methylmercury in both maternal and fetal tissues, and lower signs of mercury toxicity in the fetal brain.

from Top Health News -- ScienceDaily https://ift.tt/ply1dTI

New AI technique can uncover antiviral compounds using limited data

Artificial intelligence algorithms have now been combined with traditional laboratory methods to uncover promising drug leads against human enterovirus 71 (EV71), the pathogen behind most cases of hand, foot and mouth disease. The study showed that reliable antiviral predictions can be made even when only a modest amount of experimental data are available.

from Latest Science News -- ScienceDaily https://ift.tt/5KdGhfP

From the front garden to the continent: Why biodiversity does not increase evenly from small to large

The number of species does not increase evenly when going from local ecosystems to continental scales -- a phenomenon ecologists have recognized for decades. Now, an international team of scientists has developed a new theory to explain the three distinct phases typical of species distributions across scales. The theory may be crucial for estimating how many species are lost when habitats are destroyed.

from Latest Science News -- ScienceDaily https://ift.tt/8OJNHB2

Mechanism by which the brain weighs positive vs. negative social experience is revealed

Researchers have identified the neural mechanisms in the brain that regulate both positive and negative impressions of a social encounter, as well as how an imbalance between the two could lead to common neuropsychiatric disorders.

from Latest Science News -- ScienceDaily https://ift.tt/u5LC1z7

Mechanism by which the brain weighs positive vs. negative social experience is revealed

Researchers have identified the neural mechanisms in the brain that regulate both positive and negative impressions of a social encounter, as well as how an imbalance between the two could lead to common neuropsychiatric disorders.

from Top Health News -- ScienceDaily https://ift.tt/u5LC1z7

Dual scalable annealing processors: Overcoming capacity and precision limits

Combinatorial optimization problems (COPs) arise in various fields such as shift scheduling, traffic routing, and drug development. However, they are challenging to solve using traditional computers in a practical timeframe. Alternatively, annealing processors (APs), which are specialized hardware for solving COPs, have gained significant attention. They are based on the Ising model, in which COP variables are presented as magnetic spins and constraints as interactions between spins. Solutions are obtained by finding the spin state that minimizes the energy of the system.

from Latest Science News -- ScienceDaily https://ift.tt/kKIWDv2

Cell colonies under pressure: How growth can prevent motion

The interaction between growth and the active migration of cells plays a crucial role in the spatial mixing of growing cell colonies. This connection will lay the groundwork for new approaches to understanding the dynamics of bacterial colonies and tumors.

from Latest Science News -- ScienceDaily https://ift.tt/7eYtRTw

Ptero firma: Footprints pinpoint when ancient flying reptiles conquered the ground

A new study links fossilized flying reptile tracks to animals that made them. Fossilized footprints reveal a 160-million-year-old invasion as pterosaurs came down from the trees and onto the ground. Tracks of giant ground-stalkers, comb-jawed coastal waders, and specialized shell crushers, shed light on how pterosaurs lived, moved, and evolved.

from Latest Science News -- ScienceDaily https://ift.tt/ErKLMOb